The successful running of library automatization integrated system software lies the most on correct parameter settings. As the main participant in setting up parameters used by INNOPAC which is designed by Innovative Interfaces Inc.of United States and applied by Zhejiang Provincial Library, the authors raise four principles by which the parameters set up, along with contents: practicability, particalarity, friendliness, developing. In this thesis the authors respectively advance concrete view on how to set up system parameters scient ifically, including acquisit ion subsystem , cataloging subsystem , circulating subsystem and OPAC model’s parameter settings. The authors summarized what to attention and the experience in setting up parameters to used for reference.