基于数据立方体挖掘疾病-基因-药物新关联*

魏星, 胡德华, 易敏寒, 朱启贞, 朱文婕

Extracting Disease-Gene-Drug Correlations Based on Data Cube

Wei Xing,Hu Dehua,Yi Minhan,Zhu Qizhen,Zhu Wenjie

表2 预测部分关联程度较高但尚未证实的生物实体间新关联

Rel EN 1 Description 1 EN 2 Description 2 Disease-Gene Diabetic Neuropathies 糖尿病性神经病 IPF1 transcription factor 1 Diabetic Neuropathies 糖尿病性神经病 SUMO4 small ubiquitin-like modifier 4 Diabetic Nephropathies 糖尿病性肾病 IPF1 transcription factor 1 Diabetic Nephropathies 糖尿病性肾病 SUMO4 small ubiquitin-like modifier 4 Disease-Drug Iron Dextran 右旋糖酐铁 Diabetic Angiopathies 糖尿病性血管病 GFT505 治疗代谢综合征(MS)相关性血脂和血糖 异常的潜在新型候选药物 T2DM 2型糖尿病 Telmisartan 替米沙坦 Diabetic Neuropathies 糖尿病性神经病 Aleglitazar 阿格列扎 Diabetic Nephropathies 糖尿病性肾病 Gene-Drug IRS2 insulin receptor substrate 2 Icosapent 二十碳五烯酸 PPARG peroxisome proliferator-activated receptor gamma Icosapent 二十碳五烯酸 IRS2 insulin receptor substrate 2 Levosimendan 左西孟旦 GCK glucokinase (hexokinase 4) Levosimendan 左西孟旦 ENPP1 ectonucleotide pyrophosphatase/ phosphodiesterase 1 Myristic Acid 肉豆蔻酸