基于网络属性的抗肿瘤药物靶点预测方法及其应用*
范馨月, 崔雷

Predicting Antineoplastic Drug Targets Based on Network Properties
Fan Xinyue,Cui Lei
表4 Score≥0.9的药物靶点在癌症组织中突变及扩增情况
Gene Protein Mutation Amplification
NR5A1 Steroidogenic factor 1 Cutaneous Melanoma (3.14%) Prostate Cancer, NOS (16.92%)
CSF3R Granulocyte colony-stimulating factor receptor Penile Cancer (14.29%) Ovarian Cancer (5.71%)
NFKB2 Nuclear factor NF-kappa-B p100 subunit Cholangiocarcinoma (100%) Prostate Cancer, NOS (7.69%)
TNK2 Activated CDC42 kinase 1 Myelodysplasia (5.56%) Prostate Cancer, NOS (21.54%)
UBC Polyubiquitin-C Endometrial Cancer (2%) Prostate Cancer, NOS (12.31%)
PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta Small Bowel Cancer (5.56%) Prostate Cancer, NOS (13.85%)
IDE Insulin-degrading enzyme Endometrial Cancer (3.78%) Prostate Cancer, NOS (7.69%)
PSMB3 Proteasome subunit beta type-3 Adrenocortical Carcinoma (0.99%) Breast Cancer, NOS (18.75%)
GRM7 Metabotropic glutamate receptor 7 Ovarian/Fallopian Tube Cancer, NOS (14.29%) Prostate Cancer, NOS (23.08%)
THRA Thyroid hormone receptor alpha Colorectal Adenocarcinoma(2.91%) Breast Cancer, NOS (18.75%)
MED1 Mediator of RNA polymerase II transcription subunit 1 Cervical Cancer (4.6%) Breast Cancer, NOS (31.25%)
THRB Thyroid hormone receptor beta Cutaneous Melanoma (5.23%) Prostate Cancer, NOS (21.54%)
NCS1 Neuronal calcium sensor 1 Endometrial Cancer (0.59%) Prostate Cancer, NOS (13.85%)
NR3C2 Mineralocorticoid receptor Ovarian/Fallopian Tube Cancer, NOS (14.29%) Prostate Cancer, NOS (15.38%)
TUB Tubby protein homolog Endometrial Cancer (4.08%) Prostate Cancer, NOS (9.23%)
IL2 Interleukin-2 Cutaneous Melanoma (1.05%) Prostate Cancer, NOS (7.69%)