基于网络属性的抗肿瘤药物靶点预测方法及其应用*

范馨月, 崔雷

Predicting Antineoplastic Drug Targets Based on Network Properties

Fan Xinyue,Cui Lei

表5 5种抗肿瘤药物靶点在不同癌症组织中突变频率

癌症类型 基因名称 Melanoma Adrenocortical Carcinoma Endometrial Cancer Esophagogastric Cancer Colorectal Adenocarcinoma Cancer of Unknown Primary AR 2.09% (2.79%a,18b) 1.97% (1.97%,20) 6.08% (6.68%,4) 4.09% (4.75%,11) 4.52% (4.52%,9) 5.14% (5.24%,7) NCOA1 2.79% (3.83%,6) 1.97% (2.46%,9) 5.34% (7.42%,2) 2.47% (3.20%,7) 3.55% (3.55%,4) 4.40% (5.99%,3) JUN 0.35% (1.05%,15) 0 (0.99,-) 0.59% (0.96%,8) 0.76% (1.15%,7) 1.94% (1.94%,2) 0.47% (3.27%,11) MAPK1 1.39% (3.48%,4) 0.99% (2.96%,8) 1.19% (2.23%,6) 0.49% (1.55%,16) 0.65% (0.96%,14) 0.84% (6.08%,9) NFKB1 2.09% (2.79%,4) 0.99% (0.99%,8) 3.86% (4.15%,2) 0.73% (0.89%,13) 2.91% (2.91%,3) 6.74% (8.23%,1)