[Objective] The paper explores evolution of interdisciplinary research, aiming to identify their characteristics. [Methods] We chose “Medical Informatics” as the example of interdisciplinary study and divided its evolution into different phases. Then, we introduced interdisciplinary characteristics from the perspectives of knowledge input and output. Finally, we analyzed the co-word patterns of knowledge output to reveal the research evolution features. [Results] At the beginning, developing, and stable stages of Medical Informatics research, both the interdisciplinary degree indicators and the structural properties of the co-word network were different. At the stable stage, the knowledge began to internalize and specialize while exploding. [Limitations] The sample size of interdisciplinary fields needs to be further expanded. [Conclusions] The changing of interdisciplinary research characteristics are the results of multi-disciplinary knowledge input and output.
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