[Objective] This paper constructs an interactive impact assessment system for medical information services that integrates users, information technology and hospital staff, from the perspective of user perceived value. [Methods] The proportion of statistical indicators and the screening of indicators are proposed based on principal component analysis, the Grey clustering method determines the index correlation matrix and the critical value in order to achieving the index optimization. Establishment of combination method can evaluate the quality of medical information service evaluation system. [Results] The evaluation index system includes 58 indicators and can be divided into 9 categories. The maximum weight proportion of service value dimension is 0.2059, and the minimum weight proportion of risk cost dimension is 0.0405. [Limitations] The scale of the questionnaire data is small. The index scores are determined by a few experts and have a certain degree of subjectivity. [Conclusions] The proposed evaluation system can theoretically provide decision-making basis for hospital medical information service construction, planning and management, and improve the level of hospital medical information service and user's experience satisfaction degree in practical application.